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The primary endpoint was the percent of patients achieving a 75 percent reduction in migraine days per month from baseline to week 12. Significantly more patients achieved a ≥75 percent and ≥50 percent RR with 300 milligrams (33 percent and 57 percent) or 100 milligrams (31 percent and 55 percent) of eptinezumab than those with placebo (21 percent and 41 percent) for 12 weeks post-treatment. At randomization, HIT-6 scores averaged 64.5. HIT-6 scores for 75 percent responders receiving any study dose at week 4 were 50.9 (-13.6). Scores were sustained at 12 weeks at 52.2 (-12.3). HIT-6 scores for 50 percent responders were 57.1 at 4 weeks and 56.6 at 12 weeks. Minimal changes in HIT-6 scores were seen for ≥25 percent or All doses of eptinezumab were well tolerated, and no serious treatment-related adverse events were reported.
'These data suggest that the response rates associated with eptinezumab treatment translate into reductions in headache impact as measured by HIT-6, reflecting improvement in function and quality of life,' Dr.
Narodowy Bank Polski, NBP Visiting Researcher Program Publication date: Call for applications The Economic Research Department of Narodowy Bank Polski (NBP, central bank of Poland) invites applications for the sixth edition of the Visiting Researcher Program (VRP), which will last from March to November 2019. The VRP is aimed at enhancing cooperation of the NBP staff with both senior and young economists working on issues important from the perspective of NBP. NBP is seeking applicants whose research profile is related to central banking issues, such as monetary and macroprudential policy, international economics, financial stability or forecasting. Visiting Researchers are expected to conduct their research at the NBP headquarters for a period between one and two weeks and present their research project at an internal seminar. They will be also encouraged to submit their research paper to the NBP Working Paper series. Joint projects with NBP staff are strongly preferred. The Participants of the VRP will be offered a stimulating working environment.